公共卫生 公共卫生
Hao-Chen Chi1, Lan Tan2, Jin-Tai Yu3
1Qingdao Municipal Hospital, Qingdao, Shandong, China.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
虚弱与轻度认知障碍和阿尔茨海默病患者中抑郁,焦虑和冷漠等神经精神症状的增加有关. 大脑缩和免疫因素可能在这些联系中起作用.
科学领域:
- 老年学是指老年学的学科.
- 神经学 神经学
- 精神病学是一个精神病学.
背景情况:
- 虚弱是一种与不良健康结果相关的脆弱状态.
- 脆弱对神经心理健康的影响在很大程度上仍未被探索.
研究的目的:
- 研究轻度认知障碍 (MCI) 和阿尔茨海默病 (AD) 患者的虚弱和神经精神症状 (NPS) 之间的关联.
- 探索脆弱性和NPS之间的关系中的潜在调解因素.
主要方法:
- 利用了来自阿尔茨海默病神经成像计划 (ADNI) 2,155名参与者的数据.
- 使用修改的脆弱指数-11 (mFI-11) 评估脆弱性.
- 分析了脆弱性和NPS之间的关系,使用后勤和Cox比例危险回归模型,包括因果调解分析.
主要成果:
- 在MCI参与者中,虚弱与冷漠 (横截面) 和抑郁和冷漠 (纵向) 的风险增加有关.
- 在AD参与者中,虚弱与抑郁和焦虑 (截面) 和冷漠 (纵向) 的风险增加有关.
- 在MCI参与者中,脆弱对NPS的影响部分由海马体积,全脑体积和单细胞调解.
结论:
- 虚弱与关键的NPS有关,包括抑郁,焦虑和冷漠,跨越MCI,AD和认知进展组.
- 海马体和全脑缩,以及外周免疫力,可能是脆弱性和NPS之间观察到的关联的基础.
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