公共卫生 公共卫生
Deepika Dinesh1, Xochitl Morgan2, Tammy M Scott3
1Department of Public Health, University of Massachusetts Lowell, Lowell, MA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
肠道细菌和病毒会影响认知功能. 在波多黎各成年人中,更好的认知与更多的Faecalibacterium prausnitzii和更少的Carjivirus communis菌体有关.
科学领域:
- 微生物组研究的研究.
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
背景情况:
- 肠道微生物组和病毒组的改变与认知功能有关.
- 西班牙裔/拉丁裔面临更高的阿尔茨海默氏症风险,但肠道微生物组研究在这个人口中是有限的.
- 肠-大脑轴突出了肠道微生物与大脑之间的双向通信.
研究的目的:
- 研究与波多黎各老年人认知功能相关的肠道细菌和病毒变异.
- 解决对肠道微生物组和病毒组在该人口内认知健康的背景下理解的研究差距.
主要方法:
- 在316名参与者身上进行了便元基因组测序和认知评估 (全球认知分数 - GCS).
- 细菌和病毒的分类学概况分别使用了MetaPhlAN 4.0和BAQLaVa 1.0.
- 多变量线性回归 (MaAsLin2) 分析了微生物/病毒组成和GCS之间的关联,控制共变量.
主要成果:
- 根据GCS,没有发现总体细菌或病毒多样性 (α和β) 的显著差异.
- 较高的GCS (更好的认知功能) 与细菌Faecalibacterium prausnitzii的丰富有关 (p=0.01).
- 更糟糕的认知功能与菌体Carjivirus communis (p<0.01) 的枯竭有关.
结论:
- 酸生产细菌Faecalibacterium prausnitzii与更好的认知功能有关.
- 卡吉病毒共生,dsDNA菌体,与更差的认知功能有关.
- 肠道病毒组成可能通过调节肠道细菌来影响认知健康,这需要进一步调查细菌体-病毒体相互作用.
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