公共卫生 公共卫生
Maude Wagner1, Puja Agarwal1, Klodian Dhana2
1Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
采用健康的生活方式,以较低的LIBRA (LIFE STYLE FOR BRAIN HEALTH) 评分来表示,与更好的认知性有关. 认知刺激活动显示,尽管有大脑病理,但与保持认知的联系最强.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 认知性 (Cognitive resilience,简称CR) 是一种能力,即尽管有神经病理,仍能保持认知功能.
- 可改变的生活方式和健康因素对CR的影响尚不清楚.
研究的目的:
- 为了研究生活方式与大脑健康 (LIBRA) 指数与认知性之间的联系.
- 确定可能促进老年人认知性的特定生活方式组件.
主要方法:
- 分析了来自Rush记忆和衰老项目的585名死者.
- 进行了神经病理学检查和认知评估.
- 线性混合效应模型评估了CR (CRLevels和CRslope),线性回归检查了LIBRA指数关联.
主要成果:
- 较低的LIBRA分数与较高的CRLevels和CRslope线性相关.
- 认知刺激活动与两种CR措施的关联最强.
- 较低的LIBRA分数与没有,单个心血管疾病或单个神经退行性病理的参与者中较高的CRLevel相关.
结论:
- 改变生活方式和健康管理计划可以促进老年人的认知性.
- 针对生活方式因素的干预措施可以通过增强对神经病理的弹性来帮助维护认知健康.
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