Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Primary Healthcare Services01:30

Primary Healthcare Services

1.9K
Primary care promotes wellness and prevents disease. This care includes health promotion, education, protection (such as immunizations), early disease screening, and environmental considerations. Settings providing this type of healthcare include physician offices, public health clinics, school nursing, and community health nursing.
In 1978, international leaders convened in Alma-Ata, Kazakhstan, for what would be a pivotal event in global health. The Alma-Ata Declaration was the first to call...
1.9K
Levels of Health Promotion and Illness Prevention01:26

Levels of Health Promotion and Illness Prevention

14.1K
Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
In primary prevention, actions taken before disease onset prevent the disease from...
14.1K
Preventive Healthcare Services01:30

Preventive Healthcare Services

1.8K
Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
1.8K
Principles of Disease Surveillance01:26

Principles of Disease Surveillance

439
Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
439
Healthcare Agencies II01:17

Healthcare Agencies II

1000
There are various healthcare agencies in the United States—some of which are managed by religious institutions and others by different government branches.
Parish nursing is a growing specialty nursing profession that focuses on holistic healthcare, health promotion, and illness prevention. It blends professional nursing practice with a health ministry, focusing on health and healing within the context of a Christian community. Parish nurses serve as health educators, referral sources,...
1000
Methods Of Healthcare Delivery System01:26

Methods Of Healthcare Delivery System

3.9K
At the different levels of the healthcare system, we see varying methods of healthcare used. These methods include managed care systems, case management, and primary healthcare.
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...
3.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Kat5 cKO mouse replicates biological domain signatures associated with Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Neuroinflammation in glaucoma: a myriad of cellular pathways and players.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same author

WSB.APP/PS1 mice develop age-dependent cerebral amyloid angiopathy, cerebrovascular dysfunction, and white matter deficits.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Alzheimer's disease biological domain sub-stratification enhances the precision of functional analyses.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Mapping cross-domain drivers of Alzheimer's disease risk through integrated network analysis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Single-subject proteomic signatures in Alzheimer's disease reflect clinical phenotypes and distinguish asymptomatic from symptomatic cases.

Alzheimer's & dementia (New York, N. Y.)·2026
Same journal

Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Estimated labor market outcomes of people progressing from preclinical to early-stage Alzheimer's disease in the United States.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Amyloid exacerbates tau and alpha-synuclein pathologies, behavioral impairments, and neuroinflammation in a mixed dementia model.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
查看所有相关文章

相关实验视频

Updated: Jan 8, 2026

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
10:57

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children

Published on: August 22, 2012

24.2K

公共卫生 公共卫生

Cristian S Bernabe1, Kevin P Kotredes2, Ravi S Pandey2

  • 1Stark Neurosciences Research Institute, Indianapolis, IN, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
PubMed
概括
此摘要是机器生成的。

ATP结合盒 (ABC) 子家族A成员7 (ABCA7) 基因变异A1527G增加了阿尔茨海默氏症.

更多相关视频

Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India
09:33

Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India

Published on: December 23, 2022

2.6K
Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

相关实验视频

Last Updated: Jan 8, 2026

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
10:57

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children

Published on: August 22, 2012

24.2K
Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India
09:33

Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India

Published on: December 23, 2022

2.6K
Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

科学领域:

  • 神经科学和遗传学 在神经科学和遗传学.
  • 阿尔茨海默氏症疾病研究研究
  • 分子生物学和免疫学 分子生物学和免疫学

背景情况:

  • 全基因组关联研究 (GWAS) 确定了ATP结合盒 (ABC) 子家族A成员7 (ABCA7) 基因作为阿尔茨海默病 (AD) 的风险因素.
  • ABCA7变种与脂肪代谢中断,小质细胞化受损和粉样蛋白沉积变化有关,但确切的机制仍然不清楚.
  • ABCA7在各种脑细胞中表达,包括神经元,星球细胞和微质细胞,突出显示其在AD病变发生过程中的潜在作用.

研究的目的:

  • 调查ABCA7 A1527G变异的功能影响,这是一个假定的晚发性阿尔茨海默病 (LOAD) 风险因素,对AD的发病因子.
  • 用小鼠模型评估ABCA7*A1527G变异对LOAD的贡献.
  • 描述ABCA7*A1527G变异对不同年龄和性别的大脑代谢,炎症和粉样β (Aβ) 沉积的影响.

主要方法:

  • 在B6.APOE4.Trem2*R47H小鼠 (LOAD1和LOAD2模型) 中使用CRISPR/Cas9.9引入了ABCA7 A1527G变异.
  • 综合的表型包括行为测试,PET/CT成像,多奥米克分析,流体生物标志物测试,神经病理学和针对LOAD2.Abca7*A1527G小鼠的向蛋白质分析.
  • 在不同年龄段进行了脑半球的转录分析,以评估与Abca7*A1527G变异相关的基因表达变化.

主要成果:

  • PET/CT成像显示,在LOAD2.Abca7*A1527G小鼠中,大脑糖解和减少组织 perfusion 的性别和区域依赖性增加,表明一个未结合的表型.
  • 转录概况显示了颗粒细胞/中性粒细胞迁移和胰岛素受体信号的改变,以及大脑和血细胞因子水平的变化 (例如IL6,IL10,TNFα,IL4,IL12).
  • 较老的ABCA7队列表现出可溶和不可溶的粉样β (Aβ40和Aβ42) 的血和大脑水平升高,正在进行对斑块沉积和微细胞的组织学分析.

结论:

  • 在ABCA7的变化有助于阿尔茨海默病 (AD) 风险通过复杂的相互作用涉及大脑血管系统,微质,Aβ沉积和外围免疫细胞.
  • 该ABCA7 A1527G变种影响大脑新陈代谢和炎症,可能加剧AD病理.
  • 需要进一步的研究,以充分阐明ABCA7变种调解AD风险的机制.