公共卫生 公共卫生
Paulina Orellana1,2, Carlos Gonzalez-Carballo3, Liset Gonzalez4
1Latin American Institute for Brain Health (BrainLat), Universidad Adolfo Ibañez, Santiago, Santaigo, Chile.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
老拉丁美洲成年人的认知障碍 (CI) 与过早死亡的风险更高有关. 在认知测试中得分更高表明更好的生存率,突出了认知健康的重要性.
科学领域:
- 老年学是一门学科.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 认知障碍 (CI) 是一个已知的过早死亡风险因素.
- 关于拉丁美洲人口中CI和死亡率 (LATAM) 的研究有限.
- 这项研究研究了四个拉美国家群体中CI和全因死亡率之间的关联.
研究的目的:
- 调查四个拉丁美洲群体中老年人认知障碍和全因死亡率之间的关联.
- 确定认知表现是否是不同拉美地区人群中过早死亡的预测因素.
- 通过元分析将发现汇集在一起,以便全面了解这种关系.
主要方法:
- 一项前性队列研究,涉及多达12,990名来自智利,哥斯达黎加,墨西哥和波多黎各的60岁以上的参与者.
- 认知表现通过微型心理状态检查 (MMSE) 进行评估;CI以队列特定的切断标准来定义.
- 在不同的随访期间收集的全因死亡数据;分析包括Kaplan-Meier和多变量Cox比例危险模型与元分析.
主要成果:
- 在不同队列中,CI的患病率有显著差异 (从PREHCO的4.5%到MCPS的40.9%).
- 患有CI的个体表现出更低的生存概率.
- 分析显示,与CI相关的全因死亡率 (HR=1.52;p<0.001) 的风险增加了52%.
结论:
- 在LATAM地区,认知障碍的老年人 (≥60) 面临着显著较低的生存概率和较高的死亡风险.
- 较高的迷你精神状态考试成绩与预防过早死亡有关.
- 这些发现在各个队伍和联合元分析中都是一致的,加强了认知健康和寿命之间的联系.
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