公共卫生 公共卫生
Ibadat Warring1, Dylan X Guan2, Maryam Ghahremani2
1University of Calgary, Calgary, AB, Canada.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
高血管风险因素加快了轻度行为障碍 (MBI) 和痴呆症的出现. 管理血管风险因素可能会延缓老年人的认知衰退和行为变化.
科学领域:
- 老年学是一门学科.
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 血管风险因素 (VRF) 通过脑血管损伤与痴呆有关.
- 轻度行为障碍 (MBI) 信号通过神经精神病症状增加痴呆风险.
- 这项研究调查了在没有先前MBI或痴呆症的老年人中血管负担和MBI和痴呆症的进展之间的联系.
研究的目的:
- 检查血管负担与MBI进展之间的关联.
- 评估血管负担和从MBI到痴呆症的进展之间的关系.
- 为了确定基线认知状态是否会改变血管负担对痴呆症进展的影响.
主要方法:
- 利用来自国家阿尔茨海默氏症协调中心的8519名没有痴呆症的参与者 (≥50岁) 的数据.
- 使用弗雷明汉姆中风风险得分 (FSRS) 计算血管负担;较高的得分表明风险更大.
- 采用加速失效时间模型来分析MBI的时间和MBI到痴呆的时间,调整混因素并使用倾向分数权重.
主要成果:
- 较高的FSRS与更快的MBI进展相关 (TR:97.6%),特别是在动机下降,情感失调和冲动控制领域.
- 在FSRS和基线认知状态 (正常认知/轻度认知障碍) 之间显著的相互作用影响了痴呆症的进展.
- 较高的FSRS在MBI+个体中加速痴呆症的进展更显著,与轻度认知障碍 (TR:99.4%) 相比,MBI+个体的认知正常 (TR:95.4%).
结论:
- 升高的血管负担与加速向MBI和痴呆症的进展有关.
- 管理VRF可能会延迟MBI和痴呆的发病,特别是在认知健康的个体中.
- 建议对VRF干预措施进行进一步的研究,以增强认知和行为大脑健康.
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