公共卫生 公共卫生
Han Tong1, Ana W Capuano1, Puja Agarwal1
1Rush University Medical Center, Chicago, IL, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
饮食中低摄入量,而不是高摄入量,与老年人更快的认知衰退有关,特别是影响记忆和感知速度. 建议对和痴呆症神经病理学的进一步研究.
科学领域:
- 老年学是指老年学的学科.
- 神经科学是一个神经科学.
- 营养科学 营养科学
背景情况:
- 关于饮食中摄入量与认知功能之间的联系存在不一致的发现.
- 这项研究调查了日常摄入量与生活在社区中老年人的认知能力下降之间的关联.
研究的目的:
- 检查日常饮食摄入量与社区居住的老年人认知能力下降的速度之间的关系.
主要方法:
- 从Rush记忆和衰老项目中分析了1520名没有痴呆症的个人.
- 用每年的认知评估和食物频率问卷来估计平均7.6年的随访期间的摄入量.
- 线性混合效应模型评估了基线摄入量五分位数与认知衰退之间的关联,并根据各种健康因素进行调整.
主要成果:
- 最低五分之一的摄入量 (1764毫克/天) 与更快的全球认知衰退有关 (p=0.009).
- 在调整了BMI,血压,体力活动,饮食质量和病史后,这种关联仍然存在,但不是APOE-ε4等位基因.
- 低摄入量也与情节性记忆,语义记忆和感知速度的更快下降有关.
结论:
- 低饮食摄入量,而不是高摄入量,与老年人加速认知衰退有关.
- 记忆和感知速度领域的下降尤其明显.
- 需要进一步研究以了解摄入量与痴呆相关的神经病理之间的联系.
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