公共卫生 公共卫生
Svetlana Ukraintseva1, Hongzhe Duan1, Rachel Holmes1
1Duke University, Durham, NC, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
在75岁之前接种带状疹疫苗与阿尔茨海默病 (AD) 风险降低有关,特别是在特定遗传风险因素的女性携带者中. 早期接种疫苗可能会提供更大的AD保护.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 以前的研究表明,在接种带状疹疫苗后,阿尔茨海默病 (AD) 的风险降低了20%左右.
- 这项研究调查了带状疹疫苗接种和AD风险之间的基因型特定关联.
研究的目的:
- 检查带状疹疫苗接种与患阿尔茨海默病 (AD) 的几率之间的关联.
- 探索基因型特异性影响,特别是与rs6859 (A) 基因组相关,这是已知的AD风险因素.
主要方法:
- 后勤回归模型被用来分析来自健康和退休研究 (HRS) 和英国生物银行 (UKB) 的数据.
- 65-75岁接受带状疹疫苗的参与者与未接种疫苗的人进行了比较.
- 分析根据rs6859 (A) 等位基因的载体状态分层,rs6859 (A) 等位基因是AD的遗传风险因素.
主要成果:
- 65-75岁的带状疹疫苗接种与75岁后AD发病的几率显著降低 (OR=0.55).
- 保护性关联在rs6859 (A) 基因基因携带者中更强 (OR=0.44),特别是在女性中 (OR=0.28).
- 在75岁之前3年或更长时间接种疫苗,与两年内接种疫苗相比,风险降低更大.
结论:
- 在75岁之前接种带状疹疫苗与晚年AD的几率降低有关.
- 这种保护作用在RS6859 (A) 基因的女性携带者中更为明显.
- 支持将带状疹疫苗用于AD预防的个性化改用,早期接种疫苗可能会提供更好的保护.
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