公共卫生 公共卫生
Meiyuzhen Qi1, Ziyuan Wang1, Carol A Derby2
1University of Pittsburgh, Pittsburgh, PA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
在更年期过渡期间保持良好的心血管健康与晚年更好的认知功能有关. 在此期间采取的健康行为也可以防止认知能力下降.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 老年学是指老年学的学科.
背景情况:
- 心血管健康 (CVH) 在更年期过渡 (MT) 期间经常下降,这是影响未来阿尔茨海默氏症和相关痴呆症 (ADRD) 风险的关键时期.
- 有限的研究已经探索了整个MT的CVH状态与随后的主观认知功能之间的联系,这是ADRD的预测因素.
研究的目的:
- 为了检查心血管健康 (CVH) 变化之间的关系,使用生命的基本8 (LE8) 度量在更年期过渡期间 (MT) 和以后的主观认知功能.
- 研究LE8健康行为和健康因子子分数如何与主观认知功能的下降有关.
主要方法:
- 利用了SWAN研究的数据,包括经期前,经期前和经期后阶段的LE8评估以及随后的Ecog-12认知功能测量.
- 分类参与者的CVH状态 (低,中等,理想) 并跟踪MT (低,中等,理想,改善,恶化) 的变化.
- 采用多变量线性混合模型来分析CVH模式,LE8子得分和纵向Ecog-12得分之间的关联.
主要成果:
- 在MT期间,CVH状态低,恶化或中度的女性在主观认知功能下降的幅度明显更大,与理想CVH女性相比.
- 更好的绝经前健康行为得分与较少的认知衰退有关.
- 从更年期前到更年期前的健康行为改善也与晚年认知能力下降的减少有关.
结论:
- 在更年期过渡期间保持最佳的心血管健康对于保持认知功能至关重要.
- 在更年期前至更年期前的过渡期间采用和改善健康行为与晚年更好的认知结果有关.
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