公共卫生 公共卫生
Ethel Boccara1,2, Sapir Golan1,3, Ithamar Ganmore1
1The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Israel.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
区域脂肪分布,而不是整体体重,影响2型糖尿病老年人大脑结构. 脂肪沉积的性别特异性与大脑体积的变化有关,这凸显了个性化的认知健康方法的重要性.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 老年学是一门学科.
背景情况:
- 肥胖和2型糖尿病 (T2D) 与认知能力下降和痴呆症有关.
- 像BMI这样的全球肥胖度指标显示出不一致的结果,特别是在老年人中.
- 由于脂肪沉积的性别差异,区域脂肪分布可能提供关键的见解.
研究的目的:
- 为了研究区域脂肪沉积和T2D的老年人认知功能之间的关系.
- 为了检查区域性脂肪和阿尔茨海默病 (AD) 相关的大脑体积之间的联系.
- 确定这些关联中的潜在的性别特异性差异.
主要方法:
- 118名患有T2D的参与者接受了基于MRI的腹部脂肪测量 (肝脏,胰腺,内脏脂肪组织[VAT],皮下脂肪组织[SAT]).
- 神经心理学评估评估了全球认知,记忆,执行功能和语言.
- 大脑MRI扫描评估了灰质 (GM) 和特定的大脑区域 (海马体,额头回旋).
主要成果:
- 在两性中,肝脂肪,胰腺脂肪,VAT%或SAT%和认知表现之间没有发现显著的关联.
- 在大脑体积关联中观察到性别特异性差异:较高的肝脂肪%与女性较大的下额头 (IFG) 体积有关.
- 在男性中,较高的胰腺脂肪%与较小的上额前回 (SFG) 体积相关;较高的VAT%与较小的中回 (MTG) 体积相关,而较高的SAT%与总样本中较大的MTG体积相关.
结论:
- 在T2D的老年人中,区域性脂肪显示出与大脑结构的差异关联.
- 显著的性别特异性模式存在于脂肪分布和大脑体积之间的关系中.
- 脂肪分布和性别差异是理解肥胖对老年人群认知和大脑健康的影响的关键因素.
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