公共卫生 公共卫生
Angela Chetrit1, Nomi Carlebach1, Galit Hirsh-Yechezkel1
1Gertner Institute for Epidemiology and Health Policy, Ramat Gan, Israel, Israel.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
儿童低至中剂量电离辐射 (LMIR) 暴露并没有增加早期痴呆症 (EOD) 的整体风险. 然而,在10-15岁时的辐射显著增加了以后生活中的EOD风险.
科学领域:
- 神经科学是一个神经科学.
- 辐射瘤学 辐射瘤学
- 流行病学 流行病学
背景情况:
- 儿童中低至中等剂量的电离辐射 (LMIR) 对神经认知和痴呆风险的长期影响尚不清楚.
- 早期痴呆症 (EOD) 被定义为65岁之前诊断的痴呆症.
- 以色列的Tinea Capitis Cohort (TCC) 提供了一个独特的群体来研究这些影响.
研究的目的:
- 调查童年LMIR暴露与EOD风险之间的关联.
- 探索LMIR对神经退行性结果的潜在年龄相关影响.
主要方法:
- 该TCC包括儿童 (0-15岁) 被照射头皮感染 (1946-1960) 和匹配的对照.
- 结果数据,包括EOD和健康共变量,从国家卫生基金 (1998-2016) 收集.
- 用对竞争风险和共变量进行调整的考克斯比例危险模型来分析LMIR和EOD之间的关联,按辐射时的年龄分层.
主要成果:
- 该队列包括17,824名参与者 (7,395名被辐射).
- 在LMIR和EOD之间没有发现整体关联 (调整HR:0.91,95%CI:0.62-1.33).
- 在10-15岁被照射的人群中观察到LMIR和EOD风险增加之间的显著关联 (调整HR:2.40,95%CI:1.27-4.55).
结论:
- 儿童在10-15岁时接受辐射与EOD的风险增加有关.
- 这些发现表明LMIR的潜在长期神经退行性后果.
- 对辐射诱导的神经退行症的机制和预防策略的进一步研究是有必要的.
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