公共卫生 公共卫生
Sharon Sznitman1, Shiraz Vered2, Galit Weinstein1
1University of Haifa, Haifa, Israel.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
在老年人中使用大麻并没有显示广泛的负面认知影响. 过去和现在的使用者在某些认知领域表现更好,这表明潜在的神经保护益处和与活跃的生活方式的联系.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 心理学 心理学 心理学
背景情况:
- 大麻对老年大脑的长期认知影响尚不清楚.
- 需要进行研究来了解大麻如何影响60岁及以上个体的认知功能.
研究的目的:
- 调查过去和现在的大麻消费和认知功能之间的横截面和纵向关联.
- 为了检查英国生物银行研究中60岁以上的没有痴呆症的成年人的认知表现.
主要方法:
- 利用了来自67,713名参与者的英国生物库数据 (平均年龄为67.2).
- 采用多变量线性回归来分析大麻使用模式和认知测试 (注意力,执行功能,处理速度,记忆) 之间的关系.
- 调整了社会人口统计和生活方式的混因素;纵向分析包括后续认知得分.
主要成果:
- 前大麻使用者 (17%的样本) 在多个认知领域的表现优于从未使用者.
- 当前使用者 (4%的样本) 与从未使用者相比显示出更好的工作记忆.
- 过去频繁使用与更好的注意力有关;早期启动 (<17岁) 与更好的注意力/视觉记忆相关,但工作记忆较差. 较长的持续时间 (>5年) 与随时间推移的处理速度较慢相关.
结论:
- 大麻使用 (以前或现在) 似乎没有对老年人产生广泛的负面认知影响.
- 积极的认知关联可能来自大麻的神经保护性化合物.
- 老年人使用大麻可能与增加社会参与和更积极的生活方式相关,有利于认知健康.
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