公共卫生 公共卫生
Jenna Najar1,2,3, Robert Sigström2, Lina Jonsson2
1Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, Netherlands.
阿尔茨海默病 (AD) 的遗传风险增加了双相情感障碍 (BD) 患者的痴呆风险. 这一发现澄清了BD和痴呆症之间的联系,有助于风险评估和预防策略.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 精神病学是一个精神病学.
背景情况:
- 患有双相情感障碍 (BD) 的人患痴呆症的风险更高.
- 导致这种风险增加的特定遗传因素在很大程度上是未知的.
- 了解BD和痴呆症之间的遗传重叠对于开发有效干预措施至关重要.
研究的目的:
- 调查阿尔茨海默病 (AD) 和勒维体痴呆 (DLB) 的遗传风险因素与双相情感障碍 (BD) 患者痴呆风险之间的关联.
- 探索APOE ε4载体和多基因风险评分 (PGS) 对AD和DLB在BD患者痴呆发展中的作用.
主要方法:
- 利用来自瑞典双极收藏 (SWEBIC) 的2,238个基因型为BD的个体的数据.
- 使用国家患者登记册代码识别了痴呆症诊断.
- 计算了AD和DLB的非APOE多基因分数 (PGS),并评估了APOE ε4载体.
- 采用考克斯回归分析来检查遗传因素与痴呆风险之间的关系,并对共变量进行调整.
主要成果:
- APOE ε4载体与患有BD的个体痴呆的风险增加显著相关 (HR:1.88,p=0.007).
- 阿尔茨海默病 (AD-PGS) 的多基因风险得分较高也与痴呆风险增加有关 (HR:1.34,p=0.01).
- 在这个队列中,没有发现Lewy体痴呆症多基因风险评分 (DLB-PGS) 与痴呆症风险之间的显著关联.
结论:
- 对阿尔茨海默病的遗传倾向有助于双相情感障碍患者发展痴呆症.
- 这些发现揭示了AD和BD之间共同的遗传基础,为BD患者的痴呆病因提供了洞察力.
- 这些结果支持遗传风险分层的可能性,以及在BD人口中针对痴呆症的有针对性的预防策略.
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