公共卫生 公共卫生
Sasha Milton1, Jiahe Wei2, Haizhen Chen2
1University of California, San Francisco, San Francisco, CA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
短时间或长时间的睡眠时间,频繁的午睡和白天的睡显著增加痴呆风险,特别是在60岁及以下的个体中. 中年睡眠模式对于预防痴呆症发病至关重要.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 流行病学 流行病学
背景情况:
- 睡眠障碍越来越多地与痴呆风险有关.
- 以前的研究通常集中在老年人身上,限制了对早期生命阶段关联的理解.
- 调查不同年龄组之间的睡眠痴呆联系对于确定因果关系至关重要.
研究的目的:
- 检查睡眠时间,小睡和白天打与各种成人年龄组的痴呆风险的关系.
- 为了确定睡眠模式和痴呆风险之间的关联在中年和晚年之间是否有所不同.
主要方法:
- 分析了来自410,162名没有痴呆症的参与者的英国生物库数据.
- 评估了自我报告的睡眠变量 (持续时间,午睡,打睡).
- 考克斯模型评估了四个年龄层 (≤55,56-60,61-65,>65) 的全因痴呆 (ACD) 相关性,测试了睡眠年龄相互作用.
主要成果:
- 在13.6年的时间里,记录了7,592例发生性ACD病例.
- 短 (<6小时) 或长 (>9小时) 的睡眠时间与所有年龄段的ACD风险增加有关,最显著的是≤55和56-60.
- 经常小睡和白天打也显示出与更高的痴呆风险有显著的关联,特别是在年轻年龄组.
结论:
- 极端的睡眠时间,频繁的小睡和白天沉睡大约是痴呆症风险的两倍,60岁及以下的个体有更高的风险.
- 中年睡眠模式对痴呆风险至关重要.
- 有证据表明,睡眠障碍可能是痴呆症发病的先兆,强调了早期干预的必要性.
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