公共卫生 公共卫生
Matthew Ko1, Shirley Huang2, Karl Brown3
1University of St Andrews, St Andrews, Fife, United Kingdom.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
通过加速度计测量体力活动与老年人患痴呆症的风险较低有关. 这项技术为评估痴呆风险和促进认知健康提供了一种可靠的方法.
科学领域:
- 老年学是一门学科.
- 神经学 神经学
- 生物医学工程 生物医学工程
背景情况:
- 与年轻人相比,老年人面临着更高的痴呆风险.
- 伴随性疾病可以使痴呆症恶化,但身体活动在痴呆症发展中的作用仍然不清楚.
- 需要对体力活动进行客观测量,以了解其对痴呆风险的影响.
研究的目的:
- 通过加速度计测量身体活动与老年人痴呆症发病率之间的关联.
- 为了比较加速度计的有效性与自我报告的身体能力在预测痴呆风险.
主要方法:
- 利用了来自国家健康和衰老趋势研究 (NHATS) 的562名65岁以上的个人手腕加速度计数据.
- 使用认知测试评估事件痴呆症.
- 分析了动图测量和痴呆症之间的关联,并根据年龄,性别和并发症等共变量进行调整.
主要成果:
- 通过动图测量体力活动与较低的发病痴呆风险显著相关 (OR=0.66,95% CI [0.55-0.79]).
- 经过调整后的分析证实了这一关联 (OR=0.68,95% CI [0.57-0.82]).
- 接收器操作特征 (ROC) 曲线分析表明,加速计在预测痴呆风险方面表现优于自我报告的身体能力.
结论:
- 手腕穿戴加速度计是评估老年人身体活动的可行方法.
- 客观的体力活动测量与降低痴呆风险有显著的关联.
- 这些发现支持了这样一个假设:身体活动可以缓解认知衰退和痴呆症.
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