公共卫生 公共卫生
Susan M Landau1, Melanie J Miller2, Catherine C Conti2
1Neuroscience Department, University of California, Berkeley, Berkeley, CA, USA.
本研究探讨了将低社会经济地位 (LSES) 个体纳入阿尔茨海默病 (AD) 研究的方法. 这些发现将提高AD生物标志物研究的概括性,并为未来的国家队列招募提供信息.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物研究 生物标志物研究
- 临床试验 临床试验
背景情况:
- 阿尔茨海默病 (AD) 和阿尔茨海默病相关痴呆症 (ADRD) 研究往往缺乏普遍性,因为低社会经济地位 (LSES) 个体的代表性不足.
- 阿尔茨海默病神经成像计划 (ADNI) 计划进行一项子研究,通过探索LSES参与者参与和招收的方法来解决这一局限性.
研究的目的:
- 确定有效的策略,以吸引和招募LSES参与者参与ADRD生物标志物研究.
- 确定将LSES个人纳入ADNI等大规模AD研究计划的可行性.
主要方法:
- 利用大型医疗保健数据库来识别和联系潜在的LSES参与者.
- 与联邦合格卫生诊所 (FQHC) 合作,为LSES社区提供招聘服务.
- 招募100-200名LSES参与者,在现有或新站点进行评估,可能使用远程方法.
- 与社区组织和FQHC工作人员合作,优化招聘方法.
主要成果:
- 参与者将接受简化ADNI评估,包括临床措施,血液查和AD血生物标志物.
- 一个子集将接受神经成像 (MRI,粉样蛋白PET,蛋白PET).
- 所有数据采集和分析将与现有的ADNI协议进行协调,以实现可比性.
结论:
- 这项子研究将建立有效的方法,用于在ADRD研究中招募LSES参与者.
- 这些发现将为ADNI5的可行性提供信息,旨在建立一个反映美国人口统计的全国代表性队列.
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