公共卫生 公共卫生
Hui Chen1,2, Gulisiya Hailili3, Xue Li3
1Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
坚持MIND饮食可能会在20多年内减缓大脑缩,包括灰质损失和心室扩张. 这支持了MIND饮食.
科学领域:
- 神经科学是一个神经科学.
- 营养科学 营养科学
- 老年学是一门学科.
背景情况:
- MIND饮食与降低神经退行性疾病风险有关.
- 之前的研究表明,MIND饮食和脑成像标记物之间存在关联.
- 对于MIND饮食对大脑结构的长期影响尚不清楚.
研究的目的:
- 调查MIND饮食与纵向大脑结构变化之间的关联.
- 评估MIND饮食对脑缩随着时间的推移的影响.
主要方法:
- 利用了来自弗雷明汉心脏研究后代队列中的1647名中年和老年人的数据.
- 从1991-2001年间多次收集的经过验证的FFQ数据计算的MIND饮食得分.
- 采用线性混合模型来分析MIND饮食得分和脑成像标记者 (1999-2019) 之间的关联.
主要成果:
- 较高的MIND饮食坚持与总灰质体积 (每年0.279厘米) 的较慢下降相关.
- MIND饮食得分与侧心室体积扩张的减缓有关 (-0.071厘米/年),特别是左心室 (-0.041厘米/年).
- 这些效应占观察到的时间效应的20.1% (灰质) 和8.0-8.8% (心室).
结论:
- 对MIND饮食的更强的坚持与20年来脑缩的缓慢有关.
- 结果表明灰质损失较慢,心室扩张减少,MIND饮食的坚持更高.
- 结果支持MIND饮食对认知衰老的潜在大脑健康益处.
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