公共卫生 公共卫生
Che Henry Ngwa1, Sawsan Abdulrahim2, Meiya Saad2
1Faculty of Health Sciences, American University of Beirut, Beirut, Beirut, Lebanon.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
儿童不良经历 (ACE) 与低收入和中等收入国家 (LMICs) 的认知功能恶化有关. 对LMICs的研究是有限的,ACEs经常被测量而不考虑重症或年龄等关键特征.
科学领域:
- 公共卫生 公共卫生
- 神经科学是一个神经科学.
- 全球健康 全球健康
背景情况:
- 儿童不良经历 (ACE) 与认知能力下降有关.
- 大多数证据来自高收入国家.
- 在低收入和中等收入国家 (LMICs) 中ACE的影响需要进一步调查.
研究的目的:
- 系统地审查和对LMIC中ACE和认知功能的研究进行元分析.
- 综合关于如何在LMIC研究中报告ACE特征的发现.
主要方法:
- 来自四个电子数据库的研究的系统审查和元分析.
- 包括LMIC中老年人ACE和认知功能/损伤的研究.
- 数据提取和质量评估由两位独立作者进行.
主要成果:
- 包括13篇文章,其中情绪疏忽,父母死亡和儿童疾病是最受研究的.
- 聚合的ACE显示与认知功能有负面关联 (β = -0.27) 和与认知障碍无显著关联 (OR = 1.12).
- 在子分析中,父母的死亡和情绪上的忽视与较差的认知功能有显著的联系.
结论:
- 在LMICs中,ACE与认知功能低下和老年衰弱的风险增加有关.
- 来自LMICs的证据有限,主要来自中国.
- 需要对各种低低温国家和地区进行进一步的研究,考虑到ACE特征,如暴露频率,严重程度和年龄.
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