公共卫生 公共卫生
Blas Couto1,2, María Jose Angel Pinto3,4, Maria-Elena Avale5
1Laboratory of Progressive Neuromotor and Neurobehavioral Disorders at Instituto de Neurociencia Cognitiva y Traslacional (INCYT), CABA, Buenos Aires, Argentina.
这项研究建立了阿根廷初级陶氏病转化研究联盟 (CAITauP),为研究南美洲的渐进性上核性麻 (PSP) 和皮质细胞底综合征 (CBS) 创造了一个至关重要的队列.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 遗传学 遗传学 是一个
背景情况:
- 渐进性超核性麻 (PSP) 和皮质皮质综合征 (CBS) 是一种罕见的神经退行性疾病,其特征是tau蛋白的神经纤维状结.
- 目前PSP和CBS的流行病学数据主要来自北美,欧洲和日本,可能代表其他人口不足.
- 阿根廷转移性原病研究联盟 (CAITauP) 成立,以调查阿根廷患有这些疾病的患者的流行病学和生物学.
研究的目的:
- 建立和描述一个多中心合作倡议,研究阿根廷PSP和CBS患者的流行病学和tau生物学.
- 创建一个全面的队列,在南美洲的初级病变的翻译研究.
主要方法:
- 对患有PSP和CBS (PwPSP和PwCBS) 的人进行前性观察队列研究.
- 纵向跟踪包括深度临床表型,每12个月进行神经认知测试,并在基线收集生物样本.
- 每6个月进行一次疾病严重程度评估,并在基线时收集环境暴露史.
主要成果:
- 招募了50名患者:36人患有PSP,10人患有CBS,4人患有不分化的帕金森症和认知障碍.
- 该队列包括51%的女性,平均年龄为74岁,平均疾病持续时间为5.5年.
- 初步数据显示成功招募患者,临床表型和生物样本采集,并进行环境暴露分析.
结论:
- 在CAITauP倡议已经成功地创建了一个全面的队列的个人与PSP在阿根廷,推进患者招聘,表型,和生物银行.
- 早期的发现表明,在发展中国家的南美国家,在陶病症中进行翻译性研究的可行性.
- 该联盟旨在通过将代表性不足的南美人口纳入病学研究来增强诊断,治疗和创建试验准备的队列.
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