公共卫生 公共卫生
Christian R Salazar1, Rachel Kinder2, Michelle M Nuño3
1Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
拉丁裔加入阿尔茨海默病临床试验的意愿并不普遍低,但因遗产而异. 针对安全和后勤问题的文化定制策略对于改善参与至关重要.
科学领域:
- 神经科学是一个神经科学.
- 临床试验 临床试验
- 健康差异 在健康上的差异
背景情况:
- 在阿尔茨海默病 (AD) 临床试验中,拉丁裔的代表性不足.
- 与非西班牙裔白人 (NHW) 相比,了解不同拉丁裔子群体的参与意愿至关重要.
研究的目的:
- 为了检查拉丁裔和NHW成年人之间临床试验意愿的差异.
- 确定影响不同拉丁裔遗产群体参与的具体动机和障碍.
主要方法:
- 一项网络面板调查对1800名成年人 (50岁以上) 进行,其中包括1200名拉丁裔和600名NHW参与者.
- 参与一般和AD特定试验的意愿使用利克尔特尺度进行评估.
- 多项逻辑回归分析了意愿差异,控制了人口统计和家族史;二级分析探索了动机和障碍.
主要成果:
- 在拉丁裔和NHW之间,总体意愿并不不同,但观察到遗产特定的趋势.
- 古巴和中美洲的参与者表现出更高的意愿,而多米尼加和墨西哥的参与者与NHW相比趋势较低.
- 激励因素和障碍因遗产而异,突出需要量身定制的方法;更多的拉丁裔表示更愿意为AD专注的试验.
结论:
- 拉丁裔参与AD临床试验的意愿并不是一个统一的障碍.
- 遗产特有的差异需要文化定制的招聘策略.
- 解决安全问题,物流障碍,强调信任和社会利益,可以提高拉丁裔的参与度.
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