公共卫生 公共卫生
Luis Gustavo Sampaio1,2, Raphael Machado Castilhos3,4, Bruce Duncan5
1Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
与代谢功能障碍相关的脂肪性肝病 (MASLD) 与更快的认知衰退有关. 这项研究发现,MASLD与较低的认知功能得分和在8年内更快的下降有关.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 神经学 神经学
- 代谢综合征是代谢综合征的一种.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 越来越被认可.
- 它与认知衰退 (CD) 的关联仍在争论中,有相互矛盾的文献.
- 这项研究调查了MASLD作为ELSA-巴西队列中CD的风险因素.
研究的目的:
- 评估MASLD与认知衰退之间的关联.
- 评估MASLD对随时间推移的认知功能轨迹的影响.
- 分析MASLD在巴西成年人群认知衰退中的作用.
主要方法:
- 长度研究 (ELSA-巴西) 使用2008-2010年的数据 (第1波) 和认知评估~8年后 (第3波).
- 通过超声波诊断的MASLD,并根据肥胖症加上代谢风险因素 (肥胖症,糖尿病,高血压,脂质失调症) 定义.
- 根据年龄,性别和痴呆症风险因素调整的混合线性模型被用于评估认知能力下降.
主要成果:
- 分析了11,032名参与者;12.7%的人患有MASLD.
- 患有MASLD的个体年龄较大,男性更频繁,并患有更多的并发症.
- MASLD与显著较低的初始认知评分 (-0.15 Z 评分) 和更快的下降速度 (-0.06 Z 评分超过8年; p < 0.0001) 相关.
结论:
- MASLD与认知能力下降有显著的关联.
- 这些发现表明,MASLD可能是加速认知障碍的危险因素.
- 需要进一步的研究来探索将MASLD与认知衰退联系在一起的机制.
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