公共卫生 公共卫生
Claudia Kimie Suemoto1, Wyllians Vendramini Borelli2,3,4,5, Ismael Luis Calandri6,7
1Division of Geriatrics, University of São Paulo Medical School, São Paulo, São Paulo, Brazil.
巴西近60%的痴呆病例可以通过解决14个可修改的风险因素来预防. 针对教育和视力丧失等因素可以显著降低痴呆风险,特别是在女性中.
科学领域:
- 神经学 神经学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 2024年柳叶刀委员会确定了14个可修改的痴呆症风险因素.
- 低收入和中等收入国家 (LMICs) 由于风险因素流行率较高,为痴呆症预防提供了重大机会.
研究的目的:
- 为了确定巴西的痴呆症预防潜力,归因于14个可修改的风险因素.
- 为巴西提供第一个LMIC特定的数字,用于巴西痴呆症预防潜力.
主要方法:
- 来自ELSI-巴西研究 (2019-2021) 的50岁以上的9949名参与者的数据分析.
- 估计可修改风险因子的流行率和计算人口可归因分数 (PAF) 使用"柳叶刀"委员会相对风险.
- 主要组件分析以考虑因素共同性和按性别,种族和地区进行分层分析.
主要成果:
- 对于14个可修改的风险因素的总体PAF为59.5%.
- 关键贡献者包括教育程度较低 (9.5%),未经治疗的视力损失 (9.2%) 和中年抑郁症 (6.3%).
- 降低痴呆风险的潜力在女性 (61.1%) 比男性 (58.2%) 高,在种族和地区的PAF相似.
结论:
- 解决14个可修改的风险因素可以预防巴西近60%的痴呆病例.
- 推针对性,性别特定的公共卫生策略,以减轻巴西痴呆症负担.
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