公共卫生 公共卫生
So Yeon Jeon1,2, Min Soo Byun3,4,5, Hyeji Choi3
1Chungnam National University Hospital, Daejeon, Daejeon, Korea, Republic of (South).
这项研究估计了韩国的lecanemab资格,发现只有14.4%的临床患者和8.3%的队列参与者符合标准. 这些发现表明,需要针对韩国阿尔茨海默病治疗制定量身定制的指南.
科学领域:
- 神经学 神经学
- 临床研究 临床研究
- 阿尔茨海默病 阿尔茨海默病
背景情况:
- 在2024年5月在韩国批准的Lecanemab在现实世界中资格数据有限.
- 估计lecanemab资格对于指导韩国人口获得治疗至关重要.
研究的目的:
- 估计韩国符合莱卡尼马布治疗条件的患者比例.
- 评估临床记忆诊所群体和研究队列中的资格.
主要方法:
- 对来自大学记忆诊所的2,726名患者和来自KBASE队列的625名患者的回顾性分析.
- 适用ADRD-TWG适用使用建议 (AUR) 对于lecanemab的资格标准.
- 包括MMSE得分标准 (≥22或z-score>-1.5) 和粉样蛋白PET阳性.
主要成果:
- 在临床样本中,在应用所有标准后,有14.4%的人符合条件.
- 在队列样本中,在应用所有标准后,有8.3%的人符合条件.
- 两组的总体估计资格为8.7%.
结论:
- 这项研究为韩国人口提供了第一个真实世界的lecanemab资格数据.
- 目前的指导方针可能会排除相当一部分早期阿尔茨海默病患者.
- 需要量身定制的资格标准,反映韩国人口特征和医疗保健准入.
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