公共卫生 公共卫生
Rachel K Morgan1, Evelyn K Matei1, Tomoko Ishikawa1
1University of Michigan, Ann Arbor, MI, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
周产期 (Pb) 暴露会改变大脑和血液代谢物,影响氧化应激,炎症和脂质代谢,在雌性小鼠中观察到的效果更大. 这些发现表明Pb暴露和神经退行性疾病风险的潜在生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
- 代谢学 代谢学 代谢学
背景情况:
- 对 (Pb) 等神经毒剂的发育暴露是痴呆症的一个可疑因素.
- 痴呆症涉及神经和代谢变化,但Pb的特定代谢影响尚不清楚.
- 这项研究调查了Pb在围产期暴露后对大脑和血的代谢作用.
研究的目的:
- 评估在围产期接触后小鼠的血和大脑皮层中的代谢概况.
- 为了确定因暴露而导致的代谢变化的性别特异性差异.
- 探索潜在的暴露和神经退行性疾病的代谢生物标志物.
主要方法:
- 雌性小鼠周产期暴露于 (32ppm) 或控制水.
- 从21日出生后的后代收集血和大脑皮层.
- 使用超高性能液态染色体质谱法 (UPLC-MS) 和双向ANOVA进行代谢分析.
主要成果:
- 暴露增加了皮质和血中的氧化应激标志物,特别是在女性身上.
- 改变了皮质 (减少) 和血 (增加) 之间的炎症标志物.
- 暴露在皮层和血中都增加了脂肪酸代谢物,女性的效果更强烈.
结论:
- 产前暴露显著改变与氧化应激,炎症和脂质代谢相关的皮质和血代谢物.
- 代谢变化在雌性小鼠中通常更明显.
- 氨酸和脂肪酸代谢产物显示出作为暴露和相关神经退行性影响的生物标志物具有前途.
更多相关视频
09:33Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India
Published on: December 23, 2022
2.6K
07:20Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
Published on: January 28, 2014
37.1K
相关概念视频
Primary Healthcare Services
1.9K
Primary care promotes wellness and prevents disease. This care includes health promotion, education, protection (such as immunizations), early disease screening, and environmental considerations. Settings providing this type of healthcare include physician offices, public health clinics, school nursing, and community health nursing.
In 1978, international leaders convened in Alma-Ata, Kazakhstan, for what would be a pivotal event in global health. The Alma-Ata Declaration was the first to call...
In 1978, international leaders convened in Alma-Ata, Kazakhstan, for what would be a pivotal event in global health. The Alma-Ata Declaration was the first to call...
1.9K
Levels of Health Promotion and Illness Prevention
14.1K
Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
In primary prevention, actions taken before disease onset prevent the disease from...
In primary prevention, actions taken before disease onset prevent the disease from...
14.1K
Preventive Healthcare Services
1.8K
Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
1.8K
Principles of Disease Surveillance
439
Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
439
Healthcare Agencies II
1000
There are various healthcare agencies in the United States—some of which are managed by religious institutions and others by different government branches.
Parish nursing is a growing specialty nursing profession that focuses on holistic healthcare, health promotion, and illness prevention. It blends professional nursing practice with a health ministry, focusing on health and healing within the context of a Christian community. Parish nurses serve as health educators, referral sources,...
Parish nursing is a growing specialty nursing profession that focuses on holistic healthcare, health promotion, and illness prevention. It blends professional nursing practice with a health ministry, focusing on health and healing within the context of a Christian community. Parish nurses serve as health educators, referral sources,...
1000
Methods Of Healthcare Delivery System
3.9K
At the different levels of the healthcare system, we see varying methods of healthcare used. These methods include managed care systems, case management, and primary healthcare.
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...
3.9K
