公共卫生 公共卫生
Alvaro de Oliveira Franco1,2, Eduardo R Zimmer2, Raphael Machado Castilhos1,2
1Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
早期更年期 (EM) 与巴西妇女的认知障碍有关. 激素治疗 (HT) 可以减轻这些风险,这表明EM是认知健康的可修改因素.
科学领域:
- 神经科学是一个神经科学.
- 生殖内分泌学 生殖内分泌学
- 公共卫生 公共卫生
背景情况:
- 早期更年期 (EM) 是认知能力下降的潜在风险因素.
- 在低收入和中等收入国家,其影响未得到充分研究,因为在这些国家,痴呆的危险因素很普遍.
- 这项研究检查了EM,激素治疗 (HT) 和生殖寿命与巴西妇女的认知功能有关.
研究的目的:
- 调查早期更年期与巴西女性认知结果之间的关联.
- 探索激素治疗和生殖寿命对认知功能的影响.
- 确定早期更年期是认知障碍的可修改风险因素.
主要方法:
- 在ELSI-巴西研究中分析了4,316名绝经后妇女 (年龄≥50岁) 的数据.
- 从五个子域使用全球认知分数 (GCS) 评估认知表现.
- 线性和逻辑回归模型用于分析GCS和认知障碍的几率,控制共变量.
主要成果:
- 早期更年期 (EM) 与较低的全球认知分数 (GCS) 独立相关.
- 较长的生殖寿命 (危险年) 显示对认知有保护作用.
- 激素治疗 (HT) 与EM相互作用,显著减轻了对GCS的负面影响.
结论:
- 早期更年期是认知障碍的一个独立风险因素.
- 激素治疗可以缓解与早期更年期相关的认知衰退.
- 应对早期更年期可能是预防女性认知障碍的策略.
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