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阿尔茨海默氏症成像联盟

Alexis Moscoso1,2, Antoine Leuzy3, Lars Lau Raket4

  • 11Nuclear medicine department and Molecular Imaging Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Galicia, Spain.

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在PubMed 上查看摘要

概括
此摘要是机器生成的。

基于联合传播模型 (JPM) 的CenTauR尺度协调了不同无线电追踪器的tau-PET量化,提高了数据的可比性. 这种方法提高了tau-PET阳性率的一致性和阿尔茨海默病的诊断准确性.

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科学领域:

  • 神经成像是一种神经成像.
  • 生物标志物 生物标志物
  • 阿尔茨海默氏症疾病研究研究

背景情况:

  • 现有的tau-PET量化方法在不同放射标志物之间缺乏协调.
  • 基于联合传播模型 (JPM) 的CentTauR尺度是为了标准化tau-PET测量而开发的.
  • 本研究评估了CentTauR协调在改善数据可比性方面的有效性.

研究的目的:

  • 评估CentTauR协调如何影响使用不同标记物的匹配队列中tau-PET定量化的可比性.
  • 为了比较tau-PET阳性率,对症状性阿尔茨海默病 (AD) 的诊断准确度,以及使用Centaur的纵向变化.

主要方法:

  • 将JPM方程应用于来自561名参与者的[18F]flortaucipir SUVR数据 (ADNI和OASIS-3).
  • 通过ROC分析确定了正值的最佳CentTauR截止值.
  • 匹配了三个队列 (用[18F]flortaucipir,[18F]MK-6240和[18F]RO-948扫描) 1:1,并比较了基于CentTauR的指标.

主要成果:

  • 一个切断18CentaurRs的最佳分类[18F]flortaucipirPET的视觉读取.
  • 图-PET阳性率在所有标志物中高度可比,在Aβ阳性认知不受损的个体中有一些变化.
  • 对症状性AD和tau-PET1年变化的差异性准确性在标记剂 ([18F]flortaucipir和[18F]MK-6240) 中是相似的.

    • 结论:

    • CenTauR协调显著提高了采用不同无线电追踪器获取的tau-PET数据的可比性.
    • 目前正在进行进一步的验证,使用更大的队列和额外的追踪剂 ([18F]PI-2620).