公共卫生 公共卫生
Yanan Zhang1, Anwar T Merchant1, Jingkai Wei2
1University of South Carolina, Columbia, SC, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
从中年开始从事推的体育活动 (PA) 并没有显著减少晚年认知障碍. 需要进一步的研究来探索用于认知健康的替代长期PA策略.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 认知能力下降通常在中年开始,这表明早期干预至关重要.
- 随机对照试验 (RCT) 通常研究老年人的PA,而不是中年.
- 使用观测数据的目标试验模拟提供了一种研究长期中年干预措施的方法.
研究的目的:
- 模拟一个目标试验,评估中年开始的体育活动 (PA) 对减少认知障碍的有效性.
- 估计从中年到晚年满足PA指南对认知功能的长期影响.
主要方法:
- 对45-64岁的怀特霍尔II研究参与者的分析,没有认知障碍.
- 定义假设的PA干预为每周≥150分钟的中度至强度的PA.
- 使用参数式g公式来估计认知障碍风险,控制混因素和18年后随访损失.
主要成果:
- 包括3,309名参与者 (26%是女性,全部是白人).
- 在18年的随访期间,认知障碍的累积风险增加.
- 从中年开始启动假设的PA干预并没有显著减少认知障碍.
结论:
- 从中年开始保持推的身体活动水平并没有显示出显著的认知益处.
- 进一步的研究应该调查有效的长期PA干预措施的替代策略,从中年开始,以支持认知健康.
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