公共卫生 公共卫生
Guilherme Briczinski Souza1, Daniel Coswig Zitzke1, Gabriela Sanches1
1Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
在阿尔茨海默病 (AD) 中自我报告的语言困难与客观的语言测量相关. 患者对自己说话能力的看法与音节持续时间一致,这表明主观印象反映了实际的语言模式.
科学领域:
- 神经学 神经学
- 语音语言病理学 语言病理学
- 计算语言学 计算语言学
背景情况:
- 阿尔茨海默病 (AD) 显著影响言语和语言.
- 患者经常注意到言语变化,但客观数据缺乏,将自我感知与言语参数联系起来.
- 本研究探讨了巴西葡萄牙语说者与AD的主观语音评分和客观措施之间的关系.
研究的目的:
- 在阿尔茨海默病患者中探索自我报告的语言困难和自动语音分析之间的相关性.
- 为了确定患者对自己说话能力的看法是否与可测量的语言特征一致.
主要方法:
- 这些数据是从17个符合NINCDS-ADRDA对AD的标准的个体收集的.
- 用修改的双语语言概况 (利克尔特尺度0-6) 评估自我报告的口语能力.
- 使用工具包检查仿真语言 (TELL) 分析自发语音样本,以检查语音质量和语音时间;使用斯皮尔曼相关性.
主要成果:
- 在自我报告的口语能力和平均音节持续时间 (r = -0.522,p = 0.032) 之间观察到显著的负相关性.
- 自我报告的口语能力也与音节持续时间的变化有负相关性 (r = -0.722,p = 0.001).
- 这些发现表明,感知较低的说话能力与较长和更可变的音节持续时间有关.
结论:
- 在阿尔茨海默病中,自我感知的说话能力可靠地与音节持续时间的客观测量相关.
- 阿尔茨海默病患者对语言产生的主观印象可能反映出实际的语言模式.
- 这项研究支持了在评估语言技能时考虑患者自我判断的价值,并为进一步研究语音生物标志物开辟了道路.
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