公共卫生 公共卫生
Shanshan Wang1, Uyen-Sa Nguyen1, Zhengyang Zhou1
1University of North Texas Health Science Center, Fort Worth, TX, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
健康不良的社会决定因素 (SDOH) 与未受损的个体的认知表现较低有关. 这些关联在西班牙裔参与者中特别强烈,这表明有针对性的干预机会.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 社会学 社会学 社会学
背景情况:
- 健康的社会决定因素 (SDOH) 显著影响健康结果.
- 了解SDOH对认知功能的影响对于老年人群至关重要.
- 在SDOH的差异可能会导致跨种族/种族群体的认知衰退.
研究的目的:
- 研究多维SDOH缺点与认知能力在认知能力不受损的个体之间的关联.
- 确定这些关联是否在种族/族群之间存在差异.
主要方法:
- 利用了2294名在健康和衰老大脑研究-健康差异 (HABS-HD) 研究中认知不受损的参与者的数据.
- 使用16个指标,在经济,教育,医疗保健,社区和社会领域定义了多维的SDOH缺点.
- 使用迷你心理状态检查 (MMSE) 评估认知表现,并使用线性回归分析关联,根据年龄,性别和APOE4状态进行调整.
主要成果:
- 多维SDOH缺点与认知不受损的个体的MMSE得分较低有关.
- 社会劣势和认知之间的关联在按种族/种族分层时并不显著.
- 经济,教育,社区和医疗保健接入缺点在西班牙裔参与者中显示出更强烈的关联与认知表现,表明剂量反应关系.
结论:
- 对认知表现的SDOH缺点的影响在种族/种族群体之间有很大差异.
- 西班牙裔个体在SDOH缺点和认知衰退之间表现出更强烈的关联,突出这一群体潜在的早期干预和预防策略.
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