公共卫生 公共卫生
Jingyi Wu1, Jinyu Chen1, Juncen Wu1
1The Hong Kong Polytechnic University, Hong Kong, Hong Kong.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
认知脆弱的老年人表现出更大的认知表现的变化和流动性降低. 特定的大脑网络连接模式影响这种变化如何影响移动性,为认知衰退提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 认知心理学 认知心理学
背景情况:
- 以轻度认知障碍 (MCI) 和身体虚弱为特征的认知虚弱增加了认知衰退的风险.
- 认知个体内变异性 (IIV) 是一个关键的认知指标,更高的IIV表明了老年人认知和运动障碍的潜在早期迹象.
- 关联认知虚弱,IIV和移动性缺陷的神经机制仍未得到充分研究.
研究的目的:
- 调查大脑功能连接,认知个体内可变性 (IIV) 和认知虚弱的老年人的移动性之间的关联.
- 探索神经网络在调节IIV和认知脆弱个体的移动性表现之间的关系中的作用.
主要方法:
- 一项横截面研究比较了17名认知脆弱 (CF) 和20名非认知脆弱 (非CF) 的老年人.
- 认知脆弱是由蒙特利尔认知评估和短物理性能电池的特定分数来定义的.
- 评估包括执行功能测试 (Stroop, Trail Making),运动测试 (Timed-Up和Go - TUG) 和休息状态功能性MRI,以分析大脑网络连接和IIV分散.
主要成果:
- 与非CF相比,认知脆弱的个体显示出明显更大的IIV分散和较差的TUG表现.
- CF参与者在默认模式网络 (DMN),前端平行网络 (FEN) 和突出网络 (SMN) 中表现出减少的网络间和网络内部连接.
- DMN和FEN之间的互联网连接,特别是涉及双边中旋和双边下额头旋,缓和了CF个体的IIV分散和TUG表现之间的关联.
结论:
- 大规模的功能神经网络内部和之间改变的连接模式使认知脆弱的老年人与非认知脆弱的老年人有区别.
- 这些神经连接的差异可能解释了增加的IIV分散如何对认知脆弱的老年人的移动性表现产生负面影响.
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