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相关概念视频

Primary Healthcare Services01:30

Primary Healthcare Services

1.9K
Primary care promotes wellness and prevents disease. This care includes health promotion, education, protection (such as immunizations), early disease screening, and environmental considerations. Settings providing this type of healthcare include physician offices, public health clinics, school nursing, and community health nursing.
In 1978, international leaders convened in Alma-Ata, Kazakhstan, for what would be a pivotal event in global health. The Alma-Ata Declaration was the first to call...
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Levels of Health Promotion and Illness Prevention01:26

Levels of Health Promotion and Illness Prevention

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Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
In primary prevention, actions taken before disease onset prevent the disease from...
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Preventive Healthcare Services01:30

Preventive Healthcare Services

1.8K
Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
1.8K
Principles of Disease Surveillance01:26

Principles of Disease Surveillance

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Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
439
Healthcare Agencies II01:17

Healthcare Agencies II

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There are various healthcare agencies in the United States—some of which are managed by religious institutions and others by different government branches.
Parish nursing is a growing specialty nursing profession that focuses on holistic healthcare, health promotion, and illness prevention. It blends professional nursing practice with a health ministry, focusing on health and healing within the context of a Christian community. Parish nurses serve as health educators, referral sources,...
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Methods Of Healthcare Delivery System01:26

Methods Of Healthcare Delivery System

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At the different levels of the healthcare system, we see varying methods of healthcare used. These methods include managed care systems, case management, and primary healthcare.
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...
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相关实验视频

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Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
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公共卫生 公共卫生

Clayton O Mansel1, Soniya Mishra2, Diego R Mazzotti2

  • 1University of Kansas Alzheimer's Disease Research Center, Kansas City, KS, USA.

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PubMed
概括

多基因分数 (PGS) 显示与痴呆症患病率的相关性更高. 痴呆症患者常见的可修改风险因素可能会影响基因组风险评估,需要进一步研究.

科学领域:

  • 基因组学就是基因组学.
  • 神经科学是一个神经科学.
  • 公共卫生 公共卫生

背景情况:

  • 基因组风险评估可以通过分层和治疗预测来改善痴呆症护理.
  • 多基因分数 (PGS) 评估累积遗传风险,但对非欧洲祖先和低社会经济地位的准确性较低.
  • 涉及可修改的风险因素的基因环境相互作用可能会影响PGS准确性.

研究的目的:

  • 校准多基因分数 (PGS) 用于痴呆风险评估.
  • 为了研究PGS和12个可修改的痴呆风险因素之间的相互作用.
  • 测试高PGS在患有心脏代谢风险因素的个体中放大痴呆风险的假设.

主要方法:

  • 利用来自我们所有人研究计划的电子健康记录来确定痴呆症病例.
  • 使用全基因组测序 (WGS) 生成的多基因分数 (PGS) 对病例和对照的一个子集.
  • 采用协变量调整后勤回归来测试PGS和痴呆症诊断之间的关联.

主要成果:

  • 在245,366名参与者中,3222人患有痴呆症;高血压 (87%) 和抑郁症 (63%) 是最常见的.
  • 在PGS中,1标准偏差的增加与痴呆症诊断的增加有关 (OR:1.29 [1.05-1.58]).

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  • 世界地质系统数据包括各种祖先,其中1491人是欧洲祖先.
  • 结论:

    • 大多数痴呆症患者同时存在心脏代谢风险因素,可能会影响基因组风险评估.
    • 较高的多基因分数 (PGS) 与痴呆症患病率有关,有助于识别有风险的个体.
    • 未来的研究将探索PGS与可修改风险因素在完整数据集中的相互作用.