公共卫生 公共卫生
Pablo Aguilar1,2,3, Carmen M Colceriu2, Alex López2
1Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
在一些阿尔茨海默病研究队伍中,邻居剥夺与认知衰退有关,但研究结果各不相同. 社会经济因素和样本特征影响这些关联,突出了在阿尔茨海默病研究中需要量身定制的方法.
科学领域:
- 老年学和阿尔茨海默病的研究研究.
- 健康的社会决定因素
- 神经科学和生物标志物
背景情况:
- 可修改的风险因素和阿尔茨海默病 (AD) 生物标志物之间的关联在研究队列中可能有所不同.
- 区域贫困指数 (ADI) 是社会经济劣势的指标,正在研究其对认知和AD生物标志物的影响.
- 这项研究评估了美国 (美国POINTER成像,ADNI) 和西班牙 (UBRAIN) 队列中ADI关联的一致性.
研究的目的:
- 评估区域剥夺与认知功能和AD生物标志物之间的关系的概括性.
- 为了比较三个不同的国际研究队伍的研究结果.
- 了解社会经济因素如何影响AD病理生理学和差异.
主要方法:
- 包括美国POINTER成像 (n=1879),ADNI (n=282) 和UBRAIN (n=930) 的3091名没有痴呆症的参与者.
- 区域贫困指数 (ADI) 将社区贫困分类为低,中等和高 (美国) 或低和高 (西班牙).
- 结果包括临床前阿尔茨海默氏症认知复合物 (PACC-5),灰质体积和粉样蛋白状况;使用后勤回归模型,适时调整年龄,性别,APOE4,教育和种族/种族.
主要成果:
- 在美国的POINTER和UBRAIN中,较高的ADI与较低的PACC-5有关,但在控制教育后也没有ADNI.
- 在美国的POINTER中观察到较高的ADI与较低的灰质体积的趋势,但在ADNI或UBRAIN中没有.
- 在任何队列中都没有发现ADI和粉样蛋白状况之间的显著关联.
结论:
- 邻居剥夺和认知之间的关联在美国队伍之间以及在美国和西班牙队伍之间有很大的差异.
- 国家特定因素和样本代表性是关键考虑因素.
- 需要进一步的研究,以了解社会决定因素和AD的差异的复杂相互作用.
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