公共卫生 公共卫生
Yun Jin Chen1,2, Arlen Gaba2,3, Peng Li4,5
1Queen's University School of Medicine, Kingston, ON, Canada.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
较高的阿尔茨海默氏病多基因风险评分 (AD-PRS) 与没有痴呆症的患者的术后痴呆症 (POD) 风险增加有关. 这种关联无论睡眠负担,性别或年龄如何,都是如此.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 老年学是一门学科.
背景情况:
- 手术后痴呆症 (POD) 影响到三分之一的手术患者,增加了发病率和死亡率.
- 阿尔茨海默病 (AD) 的遗传风险因子APOE-ε4与POD有着不一致的关联.
- 调查AD的多基因风险评分 (AD-PRS) 可能会澄清POD易感性.
研究的目的:
- 为了确定较高的AD-PRS是否预测在没有先前存在痴呆症的患者中增加POD风险.
- 检查睡眠负担如何改变AD-PRS和POD风险之间的关系.
主要方法:
- 对50万英国生物库参与者的前性队列研究,平均12年随访时间.
- 通过ICD-10编码在手术后三天内发现的POD病例;不包括先前存在痴呆症的参与者.
- 考克斯的比例危险模型用于评估AD-PRS与POD风险的关联,并对共变量和睡眠负担进行调整.
主要成果:
- 与最低四分位数相比,较高的AD-PRS四分位数显示POD风险逐步增加.
- 在最高的AD-PRS四分位数 (Q3和Q4) 中的个体具有显著更高的POD风险 (HR 1.23-1.35).
- 在不同的睡眠负担水平,性别和年龄组中,AD-PRS仍然是POD风险的一致预测指标.
结论:
- 在没有痴呆症的成年人中,增加的AD-PRS独立地与增加的POD风险有关.
- 对POD的AD-PRS的预测能力在睡眠负担,性别和年龄之间是一致的.
- 研究结果表明,多基因阿尔茨海默氏症风险有助于超出APOE-ε4.4的外科妄易感.
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