公共卫生 公共卫生
Sima T Toopchiani1, Miia Kivipelto1,2, Lefkos T Middleton3
1The Ageing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London, United Kingdom, London, United Kingdom.
荷尔蒙和生殖事件显著影响女性的认知衰老,诸如怀孕和更年期等因素与记忆力和流性的急剧下降有关. 相反,晚期分娩和口服避孕药的使用在25年内显示出保护性关联.
科学领域:
- 神经科学是一个神经科学.
- 生殖内分泌学 生殖内分泌学
- 老年学是一门学科.
背景情况:
- 痴呆症患病率和认知能力下降的性别差异已经确立,但性别特异性风险因素仍然不清楚.
- 研究荷尔蒙和生殖事件在女性认知表现中的作用对于理解认知衰老至关重要.
研究的目的:
- 检查激素/生殖事件与女性认知表现之间的纵向关联.
- 在25年的时间内确定影响记忆和流性的特定生殖因素.
主要方法:
- 从怀特霍尔II研究中分析了1,398名女性公务员 (年龄在45-68岁之间) 的数据.
- 25年 (1997-2015) 的认知表现 (记忆力,语音流性) 的纵向评估.
- 混合效应模型根据人口,社会经济,血管,生活方式和其他健康因素进行调整.
主要成果:
- 语音流度的急剧下降与怀孕,更高的平价,30-34岁的第一次分娩,更短的月经周期 (≤23天) 和50岁前更年期有关.
- 相反,35岁以上的分娩,口服避孕药的使用和更长的月经周期 (35天以上) 与较慢的认知衰退有关.
- 怀孕,3岁以上的孩子,30-34岁第一次怀孕和更年期的记忆力下降也出现了类似的急剧下降.
结论:
- 荷尔蒙和生殖事件显示了与女性认知衰老的潜在长期关联.
- 对潜在机制和与其他风险因素的相互作用进行进一步研究是有必要的.
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