公共卫生 公共卫生
Carrie B Peltz1,2, Jennifer S Albrecht3, Amber L Bahorik4
1NCIRE-The Veterans Health Research Institute, San Francisco, CA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
创伤性脑损伤 (TBI) 和痴呆症之间的关系是双向的. 患有TBI的老年人在受伤前的痴呆发病率高出三倍,在TBI后的发病率甚至更高.
科学领域:
- 老年学是一门学科.
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 创伤性脑损伤 (TBI) 和痴呆的风险随着年龄的增长而增加.
- 创伤与更高的痴呆风险有关,但这种关系的双向性质尚未得到充分研究.
- 这项研究调查了急性TBI前后老年人痴呆症的发病率.
研究的目的:
- 检查急性TBI之前和之后的老年人痴呆症发病率.
- 评估退伍军人人口中TBI和痴呆症之间的双向关系.
- 为了比较TBI患者的痴呆率与非TBI对照组.
主要方法:
- 利用退伍军人卫生管理局的数据 (10/1/1999-9/30/2021) 识别55岁以上的退伍军人急性TBI.
- 根据人口统计和访问日期,与非TBI比较组 (n=41,403) 匹配的TBI病例 (n=13,801) 3: 1.
- 计算每1000人/年发生的痴呆率,比较TBI前后期和非TBI组.
主要成果:
- 患有急性TBI的退伍军人TBI前痴呆症发病率 (58.1/1000人年) 与非TBI组 (18.5/1000人年) 相比显著更高,IRR为3.1.
- 痴呆症发病率在TBI后 (72.3/1000人年) 与TBI前相比增加 (IRR为1.24).
- 平均年龄为77.8岁,TBI队列中的男性为96.5%.
结论:
- 创伤性脑损伤与痴呆症的联系是双向的,在创伤性脑损伤之前,痴呆症风险增加.
- 经过急性创伤后,老年人患痴呆症的发病率要高得多.
- 建议对老年痴呆症患者进行TBI预防,并对TBI后进行监测.
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