公共卫生 公共卫生
Anh Thy Nguyen1, Natalie Chen1, Channa Buxbaum1
1Institute for Health Metrics and Evaluation, Seattle, WA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
成年人听力损失显著增加了痴呆症的风险,特别是严重损伤. 早期干预和助听器的使用对于降低痴呆风险至关重要.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 神经学 神经学
背景情况:
- 全球有超过10亿成年人患有听力损失,这对公众健康构成重大挑战.
- 柳叶刀委员会强调了听力损失和痴呆症风险增加之间的联系.
- 之前的研究缺乏对非线性关系和研究间变化的分析.
研究的目的:
- 系统地审查和元分析与成人听力损失相关的痴呆症相对风险.
- 通过解决先前限制的新型元分析框架量化痴呆症风险.
- 探索听力损失严重程度和痴呆风险之间的剂量反应关系.
主要方法:
- 在PubMed,Embase和Web of Science (1980-2023) 的系统搜索.
- 利用证明负担 (BoP) 的元分析框架进行偏差调整和非线性分析.
- 估计的痴呆症风险在连续的分贝值使用听力测量数据.
主要成果:
- 包括38项研究,其中481,809例痴呆病例.
- 基于听力测试的分析显示,中度听力损失 (35dB) 的痴呆风险增加了29%,严重听力损失 (65dB) 的痴呆风险增加了49%.
- 二元变量分析结果显示,痴呆风险增加了31%,但不显著.
结论:
- 成年人听力损失与更高的痴呆症风险有关,特别明显在使用客观听力测试的研究中.
- 预防听力损失和促进助听器的使用对于减轻痴呆风险的战略至关重要.
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