公共卫生 公共卫生
Dvir Dori1, Bruna Seixas Lima2, Carlos Tyler Roncero2
1Rotman Research Institute-Baycrest, TORONTO, ON, Canada.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
甲状腺功能不足,包括高于正常的TSH或低于正常的FT4,不会增加认知能力下降的风险. 这项研究没有发现任何关联,警告人们不要对认知健康进行未经证实的甲状腺干预.
科学领域:
- 内分泌学 在内分泌学.
- 神经学 神经学
- 老年学是一门学科.
背景情况:
- 新兴的假设将"低于最佳"的甲状腺功能,以高正常TSH或低正常FT4为特征,与增加的认知衰退和痴呆风险联系起来.
- 这项研究调查了老年人甲状腺功能和认知状态之间的关联.
研究的目的:
- 测试"低于最佳"甲状腺功能 (高于正常TSH或低于正常FT4) 与认知衰退和痴呆症相关的假设.
- 评估甲状腺功能的临床意义在高正常和低正常范围内对认知健康.
主要方法:
- 利用了COMPASS-ND队列中的991名参与者 (50-91岁) 的数据,涵盖了一系列认知状态.
- 甲状腺功能被分类为"最佳" (TSH<2.0 μIU/ml或FT4≥16.74 pmol/L) 或"低于最佳"进行分析.
- 采用奇方位分析来评估甲状腺功能类别与认知障碍之间的关联.
主要成果:
- 对883名参与者的奇方位分析显示",低于最佳"甲状腺功能与TSH (p=0.69) 或FT4 (p=0.96) 的认知障碍之间没有显著的关联.
- 真正的甲状腺功能低下症在队列中并不常见.
- 患有高TSH水平的高百分比 (98.6%) 的参与者也表现出正常的FT4水平,这表明他们患有甲状腺功能减退症.
结论:
- 这些发现驳斥了那些认为高于正常的TSH或低于正常的FT4水平会增加认知能力下降或痴呆的风险的说法.
- 强调在重新定义TSH切断值或实施未经证实的甲状腺补充剂战略以提高认知能力方面需要谨慎.
- 表明当前的甲状腺功能参考范围适用于评估认知健康风险.
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