公共卫生 公共卫生
Aishwarya Ghosh1, Monisha S2, Thomas Gregor Issac1
1Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka, India.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
绝经后妇女的生殖期 (RP) 较长与更好的注意力和更大的大脑体积有关. 这表明,长时间暴露于雌激素可能会提供神经保护,防止与年龄相关的大脑缩.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 生殖内分泌学 生殖内分泌学
背景情况:
- 更长的生殖期 (RP),以更年期晚些时候出现为特征,与改善认知功能和降低与年龄相关的大脑缩的风险有关.
- 了解RP对绝经后妇女认知能力和大脑结构的影响,对于公共卫生战略至关重要.
研究的目的:
- 根据其生殖期的持续时间,调查绝经后妇女的认知表现和大脑体积差异.
- 为了比较城市印度人口中短期和长期生殖期的女性之间的认知功能和神经成像标记.
主要方法:
- 从塔塔长度老龄化研究中招募了583名绝经后妇女 (年龄≥45岁).
- 通过临床,认知,生化和3T MRI神经成像来评估参与者.
- 计算RP (更年期时的年龄减去初潮时的年龄) 并将女性分为短 (≤35岁) 和长 (>35岁) RP组.
主要成果:
- 短RP组的教育程度明显较低,第一次分娩的年龄较早,叶酸水平较低.
- 经过调整后的分析显示,RP较短的女性注意力功能较差 (β = -0.417,p = 0.023).
- 短RP组也显着减少了总灰质 (β = -6464.403,p = 0.026),皮质体积 (β = -4827.836,p = 0.044),以及右半球皮质体积 (β = -2971.033,p = 0.018).
结论:
- 更长的生殖期与更强的注意力,保留的灰质和更大的皮质体积在绝经后的妇女相关.
- 这些发现表明,长时间暴露于雌激素的潜在神经保护作用,可能会减轻与年龄相关的大脑缩.
- 需要进一步的研究来阐明这些关联的潜在机制和公共卫生影响.
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