公共卫生 公共卫生
Brittany Intzandt1,2, Zacharie Potvin-Jutras3,4,5, Kevin Whittingstall6
1Dr. Sandra E. Black Centre for Brain Resilience and Recovery, LC Campbell Cognitive Neurology, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
性激素对大脑血流的影响在不同年龄段的男性和女性中不同. 了解这些性别和年龄特定的关系是开发基于激素的痴呆症预防策略的关键.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 血管生物学 血管生物学
背景情况:
- 随着年龄的增长,性激素的下降会影响大脑血管健康,这是痴呆症的危险因素.
- 早期更年期是一个重要的痴呆症风险因素.
- 雌激素对女性血管和大脑健康有好处,但其对脑血管的影响尚未得到充分研究;在男性中的作用尚不清楚.
研究的目的:
- 调查循环性激素和脑血管健康标志物之间的性别和生命阶段特定关联.
- 了解雌激醇和如何影响大脑血流 (CBF),动脉过渡时间 (ATT) 和脑血管反应率 (CVR) 与衰老和更年期状态相关.
主要方法:
- 招募了187名女性 (生殖,绝经前期,绝经后期) 和157名男性 (年轻,年长).
- 使用MRI评估脑血管健康,以量化CBF,ATT和CVR.
- 测量了循环性激素水平,并进行了统计分析 (ANCOVA,多项式回归).
主要成果:
- 在女性中,雌激醇在绝经前期的个体中与ATT呈反向关系,而在绝经后的女性中与CBF和CVR有负面关联.
- 在生殖性女性中,丸激素与CVR呈现出U形关系.
- 在男性中,与年轻人中的CBF正相关,而雌激素与年长男性的CBF相反相关.
结论:
- 性激素对脑血管健康指标 (CBF,ATT,CVR) 有明显的,特定于阶段和性别的影响.
- 雌激素一般支持大脑血管健康,而丸激素显示出混合作用,在绝经后的女性中可能有害,但在年轻男性中有益.
- 这些发现凸显了定制的基于激素的干预措施的潜力,以减轻痴呆风险.
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