公共卫生 公共卫生
Hui Shi1, Loren Lipworth2, Qian Xiao3
1Vanderbilt Memory and Alzheimer's Center, Nashville, TN, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
随着时间的推移,保持一致的短时间或长时间的睡眠时间会增加阿尔茨海默氏症和相关痴呆症 (ADRD) 的风险. 睡眠模式的变化也可能表明ADRD风险增加,强调健康的睡眠预防.
科学领域:
- 老年学和睡眠科学研究
- 神经退行性疾病流行病学 神经退行性疾病流行病学
背景情况:
- 短 (<7小时) 和长 (>9小时) 的睡眠时间都与阿尔茨海默氏症和相关痴呆症 (ADRD) 风险的增加有关.
- 有限的研究已经探索了长期睡眠时间 * 轨迹 * 如何影响ADRD风险.
- 这项研究研究了随着时间的推移,睡眠持续时间的模式及其与多样化的队列中ADRD的联系.
研究的目的:
- 检查长期睡眠时间轨迹及其与发生阿尔茨海默病和相关痴呆症 (ADRD) 风险的关联.
- 为了确定与ADRD发病率增加相关的特定睡眠模式 (例如,持续短,长或持续变化).
主要方法:
- 利用了来自南方社区队列研究 (SCCS) 的数据,其中包括17,945名65岁以上的参与者参加医疗保险.
- 在4.5年的时间内,基于自我报告的睡眠 (<7,7-9,>9小时) 定义了睡眠持续时间轨迹.
- 员工调整了Cox比例危险回归来分析睡眠轨迹与通过Medicare索赔发现的事件ADRD之间的关联.
主要成果:
- 与保持健康睡眠 (7-9小时) 相比,低于最佳的睡眠持续时间轨迹与ADRD风险增加20%-69%有关.
- "长短"睡眠轨迹显示了最高的ADRD累积发病率 (HR=1.69).
- 持续短 (short-short,HR=1.20) 和长 (long-long,HR=1.56) 的睡眠时间,以及过渡 (long-healthy,short-long),与较高的ADRD风险有关.
结论:
- 随着时间的推移,保持短时间或长时间的睡眠时间与发生ADRD风险的增加有关.
- 睡眠时间的变化 (例如,从长时间睡眠过渡到短时间睡眠) 也可能是ADRD的重要危险因素.
- 在中年期间促进持续,健康的睡眠时间 (7-9小时) 对于降低患ADRD的风险至关重要.
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