公共卫生 公共卫生
Eddy Roccati1, Jessica M Collins1, Michele L Callisaya2
1Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, TAS, Australia.
定期体力活动与关键阿尔茨海默病 (AD) 血液生物标志物水平的降低有关,特别是在没有APOE-ε4基因变异的个体中. 这突出了身体活动作为痴呆症预防策略的目标.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 公共卫生 公共卫生
背景情况:
- 痴呆症越来越多地可以通过改变生活方式来预防,已经确定了14个可修改的风险因素.
- 身体活动是痴呆症中年风险的一个关键因素,与大脑生物标志物有关,但与血基标志物相比较少.
- 身体活动与基于血液的阿尔茨海默病 (AD) 生物标志物之间的关系需要进一步研究.
研究的目的:
- 为了研究身体活动和基于血液的AD生物标志物之间的关联.
- 确定阿波利波蛋白E epsilon 4 (APOE-ε4) 基因是否影响身体活动和AD生物标志物之间的关系.
主要方法:
- 来自ISLAND研究的739名健康参与者填写了体育活动问卷,并提供了血液样本.
- 分析的血液生物标志物包括血清神经丝光 (NfL),血清质纤维酸性蛋白质 (GFAP) 和血酸化tau 181 (p-tau 181).
- 通用线性回归模型评估了身体活动 (MET评分) 和AD生物标志物之间的关联,考虑到APOE-ε4状态.
主要成果:
- 较大的体力活动与较低的血清GFAP水平显著相关.
- 这种关联是由APOE-ε4状态调节的;它在APOE-ε4阴性中是显著的,但在APOE-ε4阳性中没有.
- 剧烈的体力活动显示出与血清GFAP的最强相关性,而轻度和中度活动则没有.
- 身体活动和p-tau 181或NfL之间没有发现显著的关系.
结论:
- 身体活动与血清GFAP有关,这是AD的血液生物标志物.
- APOE-ε4基因型改变了身体活动和GFAP之间的关联.
- 身体活动是社区干预措施的一个有希望的目标,旨在减少痴呆风险及其早期生物标志物.
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