公共卫生 公共卫生
Gelanys Castro1, Lawrence S Honig2,3, Howard F Andrews1
1Columbia University, New York, NY, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
追踪大脑捐赠讨论显著增加了不同人群的捐赠率,解决阿尔茨海默病研究中的代表性不足问题. 这种方法促进了对关键神经退行性研究的更大参与和承诺.
科学领域:
- 神经科学是一个神经科学.
- 医学研究 医学研究
- 公共卫生 公共卫生
背景情况:
- 美国医学研究中西班牙裔和黑人参与者的代表性不足,特别是阿尔茨海默病 (AD) 和相关痴呆症 (ADRD),造成了知识差距.
- 这些差距延伸到AD/ADRD流行病学,病理生物学,治疗方法和死后研究.
- 哥伦比亚大学欧文医疗中心 (CUIMC) 的阿尔茨海默病研究中心 (ADRC) 旨在通过社区参与和招生来减少这些差异.
研究的目的:
- 报告ADRC内部加强脑捐赠讨论和承诺的努力.
- 检查这些讨论与完成的大脑捐赠之间的关系.
- 通过改善代表性不足的群体的参与来解决AD/ADRD研究中的健康差异.
主要方法:
- 优先考虑真实的社区参与,使用双语 (西班牙语/英语) 材料和人员.
- 大脑尸检不是ADRC的入学标准,而是计划中的讨论点.
- 自2000年以来,实施了一种系统来追踪参与者对大脑捐赠的兴趣,促使协调员对此进行跟踪.
主要成果:
- 自2005年以来,哥伦比亚ADRC促进了1663次大脑捐赠.
- 在2,356名被评估的个人中,有1,127人 (47.8%) 进行了记录的脑捐赠讨论,导致了445个协议.
- 记录的意图与捐赠有很强的关联,81.0%的人以后会谈捐赠. 意图因种族-民族群体而异: 73.3%是白人,60.0%是西班牙裔,55.1%是黑人.
结论:
- 启动和跟踪大脑捐赠对话增加了捐赠的可能性.
- 大多数种族和民族群体在讨论后表示愿意捐赠.
- 基于社区的参与式研究方法是可行的,以提高在代表性不足的人口中大脑捐赠率.
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