基础科学和病原发生学
Kavisha Sandaru Katuwawala1, Warnakulasuriya Mary Ann Dipika Binosha Fernando2,3, Prashant Bharadwaj4
1EDITH COWAN UNIVVERSITY AUSTRALIA, Perth, Western Australia, Australia.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
便微RNAs (miRNAs) 显示为阿尔茨海默病 (AD) 诊断和监测的非侵入性生物标志物具有前途. 改变肠道微生物组相关的miRNAs可能为AD提供新的治疗点.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 遗传学 是一个遗传学.
背景情况:
- 阿尔茨海默病 (AD) 是一种与肠道微生物群相关的神经退行性疾病.
- 肠-大脑通信,涉及便微RNAs (miRNAs),在AD病变发生过程中至关重要.
- 便中的miRNAs为AD诊断和治疗目标提供了非侵入性生物标志物.
研究的目的:
- 审查便miRNA资料在阿尔茨海默病中的意义.
- 专注于它们在早期诊断,疾病监测和治疗干预方面的作用.
- 在AD中通过便miRNAs检查肠-大脑轴连接.
主要方法:
- 从2010年到2023年进行系统的文献搜索 (PubMed,Scopus,科学网,谷歌学者).
- 包括关于便miRNA表达,肠-大脑通信和AD生物标志物的研究.
- 分析了40篇临床和临床前研究文章.
主要成果:
- 关键的miRNAs (miR-146a,miR-155,miR-34a) 在AD中失调,与神经炎症和突触功能障碍有关.
- 特定的miRNAs (miR-132,miR-181c) 与认知衰退和AD严重程度相关.
- 临床前研究表明,饮食干预和益生菌调节便miRNAs,表明治疗潜力.
结论:
- 便miRNA概况提供了关于AD肠-大脑轴的见解,作为有前途的非侵入性生物标志物.
- 改变的miRNA表达反映了肠道失调和神经炎症,表明潜在的治疗点.
- 需要进一步的临床试验和对饮食/益生菌干预措施的研究来管理AD.
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