基础科学和病原发生学
João Vitor Bittencourt Venera1
1UNIFEBE, Balneário Camboriú, Santa Catarina, Brazil.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
沉浸式虚拟现实 (iVR) 显示出对评估阿尔茨海默病 (AD) 和轻度认知障碍 (MCI) 的承诺,检测早期AD迹象. 然而,它在AD患者的认知训练中的有效性需要通过随机对照试验进行进一步的研究.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 康复技术 康复技术 康复技术
背景情况:
- 阿尔茨海默病 (AD) 导致认知能力逐渐下降,传统治疗的成功程度有限.
- 沉浸式虚拟现实 (iVR) 为阿兹海默症患者的认知评估和康复提供了新的机会.
- iVR的交互式环境可以定制用于治疗干预,以潜在地改善认知功能和生活质量.
研究的目的:
- 系统地审查iVR在评估和治疗阿尔茨海默症或轻度认知障碍 (MCI) 患者中的使用.
- 评估iVR干预措施的可接受性,可行性和有效性.
- 探索IVR与神经解剖学基质和现有的查方法的相关性.
主要方法:
- 对使用iVR用于AD/MCI评估和治疗的研究进行系统审查.
- 搜索的数据库:Medline,PsycINFO,Embase,CINAHL,以及科学网. 在这些数据库中进行了搜索.
- 专注于IVR的可接受性,可行性,有效性以及与神经解剖学和查的相关性.
主要成果:
- 九项研究符合纳入标准;参与者可以很好地容忍IVR.
- 一项研究表明,iVR可以检测出前进性AD,与神经解剖学变化相关.
- 在两项研究中,iVR将AD患者与对照患者区分开来,但缺乏强大的对照;认知训练显示了积极的反,但效益不一致.
结论:
- iVR是评估老年人和AD患者的一个有希望的工具,特别是当与神经退行模型和查方法相结合时.
- 对于阿尔茨海默病的认知训练,IVR的治疗效果仍然没有确定性.
- 需要进一步的随机对照试验来验证iVR在AD评估和认知康复中的有效性.
相关概念视频
Infection
11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology
524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis
676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology
2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection
64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens
2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K


