公共卫生 公共卫生
Allison Gibson1, Dimitra Tziarli2
1St. Louis University, St. Louis, MO, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
为阿尔茨海默病和相关痴呆症 (ADRD) 临床试验招募受限于正规教育的成年人需要有针对性的沟通和社区信任建设. 解决特定障碍对于包容和公平的研究参与至关重要.
科学领域:
- 临床研究 临床研究
- 公共卫生 公共卫生
- 健康 公平 卫生 公平
背景情况:
- 阿尔茨海默氏症和相关痴呆症 (ADRD) 临床试验经常过度代表具有高等教育和社会经济地位的个人.
- 有限的正规教育与更高的慢性疾病率和更差的健康结果有关,这可能会影响试验风险和反应.
- 伦理准则要求在研究中包容,以防止偏见,并确保公平地分配治疗的好处和风险.
研究的目的:
- 探索现有的关于招募具有有限正规教育的成年人参加ADRD临床试验的最佳实践的研究.
- 确定加强代表性不足的人群参与ADRD研究的策略.
主要方法:
- 进行了学术文献的系统范围审查.
- 在多个数据库中,搜索包括与"低教育水平"或"有限的正规教育"和"临床研究参与"或"临床试验注册"相关的术语.
- 符合条件的文章提供了克服临床试验参与障碍或支持促进者的建议.
主要成果:
- 综述中包括了28篇文章.
- 研究结果表明,对于受限于正规教育的参与者来说,需要有针对性的沟通和关系建设策略.
- 确定了这群人群参与试验的几个额外障碍.
结论:
- 有效的招聘策略包括通过对研究过程及其重要性的教育来建立社区信任.
- 通过创新方法识别和解决社区特定的障碍,对于成功参与试验至关重要.
- 建议采用有针对性的沟通策略,以提高ADRD临床试验的包容性.
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