公共卫生 公共卫生
Soo Jung Kang1, Jeanette Gustat1, Wan Tang1
1Celia Scott Weatherhead Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
从童年到中年,血管风险因素 (VRF) 的高变化,如血压和葡萄糖,与中年认知功能较差有关. 管理VRF变化可能有助于认知健康.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 心脏病学 心脏病学
背景情况:
- 血管风险因子 (VRF) 的变化,而不仅仅是平均水平,与痴呆风险有关.
- 多个VRF的长期变异性对中年认知功能 (CF) 的影响尚不清楚.
研究的目的:
- 研究从童年到成年期的VRF变异性对中年CF的复合和相对影响.
- 评估系统血压 (SBP),禁食血葡萄糖 (FPG),非高密度脂蛋白胆固醇 (非HDL) 和体重指数 (BMI) 的变化如何影响认知表现.
主要方法:
- 利用波加卢萨心脏研究的数据,从童年到中年至少进行了3次VRF测量.
- 使用变化系数 (CV) 计算长期VRF变化率 (VRFV).
- 通过全球认知得分 (GCS) 和对神经心理 (NP) 测试的集群分析,开发了一种加权的复合可变性得分 (WCS),并通过全球认知得分 (GCS) 评估中年CF.
主要成果:
- 在SBP和FPG的最高变化显示了对中年CF最大的负面影响.
- 较高的WCS与降低GCS和低于最佳认知概率的概率增加有关.
- 具体来说,最高的WCS三位数与0.1GCS下降和77%更高的混合低认知功能的几率相关.
结论:
- 在整个生命过程中VRF的变化显著影响中年认知功能.
- 从童年开始准VRF变化可能是维护认知健康的关键策略.
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