公共卫生 公共卫生
Sumedha Mitra1, Jonas S Sundarakumar1,
1Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka, India.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
血清皮质醇水平较低,而不是较高,与老年人注意力较差和睡眠药物的使用增加有关. 这表明上腺功能缺陷在认知衰退和睡眠障碍中的潜在作用.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
背景情况:
- 关于血清皮质醇水平与老年人群认知表现之间的关联,存在不同的发现.
- 以前的研究不一致地将更高的皮质醇与较差的认知能力和减少的大脑体积联系在一起.
- 皮质醇和认知之间的关系在印度人群中仍未得到充分研究.
研究的目的:
- 调查基线血清皮质醇水平与老龄化印度人口认知表现之间的关联.
- 探索皮质醇水平,认知功能和睡眠质量之间的关系.
- 检查大脑MRI上皮质醇水平和白质超强度 (WMH) 量之间的潜在相关性.
主要方法:
- 从CBR-SANSCOG研究中对609名南印度成年人 (≥45岁) 的横截面分析.
- 血清皮质醇水平测量和分类为低 (≤3mcg/dL),正常 (>3和<18mcg/dL) 或高 (≥18mcg/dL).
- 使用HMSE和COGNITO评估认知功能;通过PSQI评估睡眠质量;从3TMRI分析WMH体积.
主要成果:
- 低血清皮质醇水平与听觉注意力任务的表现差显著相关 (p=0.01).
- 皮质醇水平较低的个体报告睡眠药物的使用增加 (PSQI组件6,p=0.001).
- 探索性分析显示,在FDR校正后,皮质醇和WMH体积之间没有显著的关联.
结论:
- 血清皮质醇水平较低,而不是较高,与注意力受损和老年人对睡眠药物的依赖程度增加有关.
- 研究结果表明,上腺功能不充分可能在认知功能和睡眠质量方面发挥作用.
- 需要进一步研究上腺功能不全的诊断标准,以证实这些关联.
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