公共卫生 公共卫生
Caimei Luo1, Ruihan Wang1, Feng Yang1
1West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
综合饮食抗氧化剂指数 (CDAI) 的高得分与痴呆和阿尔茨海默病 (AD) 的风险降低有关. 这种饮食方法可以通过影响炎症和大脑结构来帮助减少痴呆风险.
科学领域:
- 营养科学 营养科学
- 神经科学是一个神经科学.
- 流行病学 流行病学
背景情况:
- 综合饮食抗氧化剂指数 (CDAI) 衡量了富含抗氧化剂的饮食.
- 在此之前,CDAI与痴呆风险之间的联系尚未被探索.
- 了解这种关系对于公共卫生至关重要.
研究的目的:
- 调查CDAI和痴呆风险之间的关联.
- 探索CDAI在痴呆症亚型中的作用,包括阿尔茨海默病 (AD) 和血管痴呆症 (VD).
- 阐明潜在的机制,重点关注炎症和大脑结构.
主要方法:
- 对157742名没有痴呆症的英国生物库参与者的前性分析.
- 通过24小时的回忆,从饮食中摄入6种抗氧化剂的CDAI计算出来.
- 考克斯的比例危险模型和受限立方线用于评估关联和非线性相关性.
- 调解分析探索了炎症标志物和大脑结构.
主要成果:
- 较高的CDAI得分显示,与所有原因痴呆症和AD的风险降低有显著关联.
- 观察到L形非线性关联,风险明显降低到特定CDAI值以下.
- 炎症标志物部分调解了这种关联;在一些分析中,CDAI与大脑体积有正相关.
结论:
- 在CDAI和痴呆症/AD风险之间存在非线性,L形的关联.
- CDAI显示出作为痴呆症生物标志物和饮食干预目标的潜力.
- 对炎症和大脑结构的有益影响表明了潜在的机制.
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