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相关概念视频

Primary Healthcare Services01:30

Primary Healthcare Services

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Primary care promotes wellness and prevents disease. This care includes health promotion, education, protection (such as immunizations), early disease screening, and environmental considerations. Settings providing this type of healthcare include physician offices, public health clinics, school nursing, and community health nursing.
In 1978, international leaders convened in Alma-Ata, Kazakhstan, for what would be a pivotal event in global health. The Alma-Ata Declaration was the first to call...
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Levels of Health Promotion and Illness Prevention01:26

Levels of Health Promotion and Illness Prevention

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Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
In primary prevention, actions taken before disease onset prevent the disease from...
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Preventive Healthcare Services01:30

Preventive Healthcare Services

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Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
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Principles of Disease Surveillance01:26

Principles of Disease Surveillance

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Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
439
Healthcare Agencies II01:17

Healthcare Agencies II

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There are various healthcare agencies in the United States—some of which are managed by religious institutions and others by different government branches.
Parish nursing is a growing specialty nursing profession that focuses on holistic healthcare, health promotion, and illness prevention. It blends professional nursing practice with a health ministry, focusing on health and healing within the context of a Christian community. Parish nurses serve as health educators, referral sources,...
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Methods Of Healthcare Delivery System01:26

Methods Of Healthcare Delivery System

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At the different levels of the healthcare system, we see varying methods of healthcare used. These methods include managed care systems, case management, and primary healthcare.
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...
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Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
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公共卫生 公共卫生

Nigus G Asefa1, Tesfa Dejenie Habtewold2, Valborg Gudmundsdottir3

  • 1Laboratory of Epidemiology and Population Sciences, National Institute on Aging, BALTIMORE, MD, USA.

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PubMed
概括
此摘要是机器生成的。

产前环境会影响以后的健康. 出生大小全基因组关联研究 (EWAS) 通过DNA甲基化变化将早期生活因素与认知衰退联系起来.

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科学领域:

  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
  • 健康和疾病的发育起源 (DOHaD)
  • 神经科学是一个神经科学.

背景情况:

  • 不良的产前环境越来越多地与生命后期不良的健康结果有关.
  • 早期的生活暴露可以塑造长期的健康轨迹.
  • 了解这些早期影响对于公众健康至关重要.

研究的目的:

  • 调查出生大小与生命晚期DNA甲基化之间的关联.
  • 根据出生大小开发一个表观遗传分数.
  • 评估这种表观遗传分数和认知功能之间的关系.

主要方法:

  • 全表观基因组关联研究 (EWAS) 在795名参与者从年龄,基因/环境敏感性-雷克雅未克研究 (AGES-RS).
  • 分析出生体重和长度数据 (1914-1935) 和晚年DNA甲基化 (MethylEPIC V1 BeadChip).
  • 构建一个表观遗传分数,并评估其与认知功能的关联,调整共变量.

主要成果:

  • 出生大小与cg24617612的甲基化显著相关,并且与其他47个cpg位点有暗示.
  • 相关的CpG位点与神经发育异常,血管炎症和环境暴露有关.
  • 表观遗传分数的增加与记忆分数的下降相关.

结论:

  • 晚年DNA甲基化模式与认知能力下降有关.
  • 产前暴露可能会影响表观遗传特征和长期健康.
  • 生命早期的因素在塑造表观遗传修饰和健康结果方面发挥着重要作用.