公共卫生 公共卫生
Ethan C Cicero1, Jason D Flatt2, Vin Tangpricha1
1Emory University, Atlanta, GA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
与 cisgender 男人和女人相比,变性女性成年人患阿尔茨海默病和相关痴呆症 (ADRD) 的患病率更高. 这种增加的风险与性别肯定激素治疗 (GAHT) 无关.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 在跨性别人群中对阿尔茨海默病和相关痴呆症 (ADRD) 患病率的理解有限.
- 关于转女性 (TF) 成人中ADRD风险增加的不确定性,特别是那些使用性别肯定激素治疗 (GAHT) 的人.
研究的目的:
- 为了调查ADRD在变性女性 (TF) 成年人中的患病率,与 cisgender 男人 (CM) 和 cisgender 女人 (CW) 相比.
- 确定性别肯定性激素治疗 (GAHT) 是否影响FT成年人ADRD风险.
主要方法:
- 使用电子健康记录 (2006-2023) 对2,362名TF成年人 (年龄在45岁以上) 进行匹配,每个人10CM和10CW.
- 计算的几率比率 (OR) 和95%的置信区间 (CI) 来比较ADRD的流行率.
- 进行了TF个体的子组分析,使用GAHT和TF个体的颜色.
主要成果:
- 与CM (0.8%) 和CW (0.9%) 相比,TF成年人表现出较高的ADRD患病率 (1.8%).
- 与CM (OR=2.3) 和CW (OR=1.9) 相比,TF成年人患ADRD的几率大约是两倍.
- 使用GAHT并没有显著改变观察到的TF状态和ADRD之间的关联.
结论:
- 变性女性成年人患ADRD的患病率明显高于同类 cisgender 个体.
- 在TF成年人中增加的ADRD风险不能归因于性别肯定激素治疗 (GAHT).
- 未来的研究应该探索可修改的风险因素 (例如,社会隔离,高血压,肥胖) 使用终身方法.
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